Assay Detail
Binding
CHEMBL4034784
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Inhibition of ERK phosphorylation in human MDA-MB-231 cells after 1 hr
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.17 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.20 |
| CHEMBL4065808 | — | — | 1 | 5.52 |
| CHEMBL4075216 | — | — | 1 | 5.52 |
| CHEMBL4077816 | — | — | 1 | 5.44 |
| CHEMBL4068198 | — | — | 1 | 5.36 |
| CHEMBL4070208 | — | — | 1 | 5.34 |
| CHEMBL4086582 | — | — | 1 | 5.26 |
| CHEMBL4068744 | — | — | 1 | 5.26 |
| CHEMBL4070561 | — | — | 1 | 5.26 |
| CHEMBL4092194 | — | — | 1 | 5.22 |
| CHEMBL4061653 | — | — | 1 | 5.21 |
| CHEMBL4064772 | — | — | 1 | 5.16 |
| CHEMBL4083343 | — | — | 1 | 5.16 |
| CHEMBL4075949 | — | — | 1 | 5.12 |
| CHEMBL4060594 | — | — | 1 | 5.09 |
| CHEMBL4077480 | — | — | 1 | 5.05 |
| CHEMBL4071674 | — | — | 1 | 5.05 |
| CHEMBL4092469 | — | — | 1 | 4.68 |
| CHEMBL4075814 | — | — | 1 | 4.68 |
| CHEMBL4082197 | — | — | 1 | 4.53 |
| CHEMBL4093413 | — | — | 1 | 4.52 |
| CHEMBL4063962 | — | — | 1 | 4.16 |
| CHEMBL4067615 | — | — | 1 | - |
| CHEMBL4088842 | — | — | 1 | - |
| CHEMBL4094137 | — | — | 1 | - |
| CHEMBL4076325 | — | — | 1 | - |
| CHEMBL4082537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4065808 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4075216 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4077816 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL4068198 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4070208 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4086582 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4068744 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL4070561 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4092194 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4061653 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL4064772 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4083343 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4075949 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4060594 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4077480 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4071674 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4092469 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4075814 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4082197 | — | IC50 | = | 29680.0 | nM | 4.53 |
| CHEMBL4093413 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4063962 | — | IC50 | = | 69860.0 | nM | 4.16 |
| CHEMBL4067615 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4088842 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4094137 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4076325 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4082537 | — | IC50 | > | 100000.0 | nM | - |