Assay Detail
Binding
CHEMBL4034965
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Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk2 (CHEMBL2527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.64 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072515 | — | — | 1 | 8.26 |
| CHEMBL4093249 | — | — | 1 | 8.16 |
| CHEMBL4063921 | — | — | 1 | 7.83 |
| CHEMBL4085496 | — | — | 1 | 7.75 |
| CHEMBL4090789 | — | — | 1 | 7.51 |
| CHEMBL195041 | — | — | 1 | 7.50 |
| CHEMBL4100980 | — | — | 1 | 7.49 |
| CHEMBL4103039 | — | — | 1 | 7.48 |
| CHEMBL4062848 | — | — | 1 | 7.47 |
| CHEMBL4083002 | — | — | 1 | 7.32 |
| CHEMBL4076911 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072515 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4093249 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4063921 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL4085496 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL4090789 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL195041 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4100980 | — | IC50 | = | 32.5 | nM | 7.49 |
| CHEMBL4103039 | — | IC50 | = | 33.4 | nM | 7.48 |
| CHEMBL4062848 | — | IC50 | = | 33.8 | nM | 7.47 |
| CHEMBL4083002 | — | IC50 | = | 48.4 | nM | 7.32 |
| CHEMBL4076911 | — | IC50 | = | 52.8 | nM | 7.28 |