Assay Detail
Binding
CHEMBL4035007
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Inhibition of recombinant full length Anopheles gambiae AChE1 G122S mutant expressed in baculovirus-infected Sf9 insect cells using acetylthiocholine iodide as substrate measured over 60 secs by Ellman's method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Anopheles gambiae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.39 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075136 | — | — | 1 | 4.77 |
| CHEMBL4071394 | — | — | 1 | 4.66 |
| CHEMBL1340607 | — | — | 1 | 4.62 |
| CHEMBL4079963 | — | — | 1 | 4.48 |
| CHEMBL4064806 | — | — | 1 | 4.30 |
| CHEMBL4073401 | — | — | 1 | 4.18 |
| CHEMBL4092186 | — | — | 1 | 4.08 |
| CHEMBL4099934 | — | — | 1 | 4.03 |
| CHEMBL1482486 | — | — | 1 | - |
| CHEMBL4081932 | — | — | 1 | - |
| CHEMBL1543212 | — | — | 1 | - |
| CHEMBL1416246 | — | — | 1 | - |
| CHEMBL4087841 | — | — | 1 | - |
| CHEMBL1301463 | — | — | 1 | - |
| CHEMBL4104206 | — | — | 1 | - |
| CHEMBL4100253 | — | — | 1 | - |
| CHEMBL4095547 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075136 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4071394 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1340607 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4079963 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4064806 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4073401 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL4092186 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL4099934 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL1482486 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4081932 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1543212 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1416246 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4087841 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1301463 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4104206 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4100253 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4095547 | — | IC50 | > | 200000.0 | nM | - |