Assay Detail
Binding
CHEMBL4035009
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Inhibition of AChE1 in Anopheles gambiae head extract using acetylthiocholine iodide as substrate measured over 60 secs by Ellman's method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Anopheles gambiae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.94 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092186 | — | — | 1 | 6.72 |
| CHEMBL4064806 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092186 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4064806 | — | IC50 | = | 7100.0 | nM | 5.15 |