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Assay Detail

CHEMBL4035127

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-LSD from human 5-HT6R expressed in human HeLa cells after 1 hr by liquid scintillation counting method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HeLa
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 6 (CHEMBL3371)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine.
Łażewska D, Kurczab R, Więcek M, Kamińska K, Satała G, Jastrzębska-Więsek M, Partyka A, Bojarski AJ, Wesołowska A, Kieć-Kononowicz K, Handzlik J.
Eur J Med Chem (2017) 135 : 117 -124
PubMed 28441580 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.20 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL431298 1 9.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL431298 Ki = 0.631 nM 9.20