Assay Detail
Functional
CHEMBL4035255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplatelet activity in human platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 2 mins followed by arachidonic acid addition by turbidimetric method relative to control
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridine derivatives as non-anionic antiplatelet agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.99 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065493 | — | — | 1 | 5.43 |
| CHEMBL4071381 | — | — | 1 | 5.43 |
| CHEMBL4084418 | — | — | 1 | 5.43 |
| CHEMBL4062734 | — | — | 1 | 5.43 |
| CHEMBL4089783 | — | — | 1 | 5.43 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 4.42 |
| CHEMBL11662 | OZAGREL | 4.0 | 1 | 4.28 |
| CHEMBL4099918 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065493 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4071381 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4084418 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4062734 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4089783 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL25 | ASPIRIN | IC50 | = | 37600.0 | nM | 4.42 |
| CHEMBL11662 | OZAGREL | IC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL4099918 | — | IC50 | = | 78900.0 | nM | 4.10 |