Assay Detail
Functional
CHEMBL4035287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A375M cells harboring BRAF V600E mutant after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A375M |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.12 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 6.30 |
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 5.89 |
| CHEMBL4084498 | — | — | 1 | 5.36 |
| CHEMBL4103398 | — | — | 1 | 5.10 |
| CHEMBL4100958 | — | — | 1 | 4.62 |
| CHEMBL4081990 | — | — | 1 | 4.59 |
| CHEMBL4062822 | — | — | 1 | 4.55 |
| CHEMBL4074200 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL43482 | MITONAFIDE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4084498 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4103398 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4100958 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4081990 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL4062822 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL4074200 | — | IC50 | = | 28700.0 | nM | 4.54 |