Assay Detail
Functional
CHEMBL4035290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHL-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.32 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 6.30 |
| CHEMBL4084498 | — | — | 1 | 6.10 |
| CHEMBL4074200 | — | — | 1 | 5.29 |
| CHEMBL4103398 | — | — | 1 | 5.12 |
| CHEMBL4062822 | — | — | 1 | 5.05 |
| CHEMBL4100958 | — | — | 1 | 4.96 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 4.90 |
| CHEMBL4081990 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4084498 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4074200 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4103398 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4062822 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4100958 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4081990 | — | IC50 | = | 13500.0 | nM | 4.87 |