Assay Detail
Binding
CHEMBL4035440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat serum BuChE using butyrylthiocholine chloride as substrate after 15 mins by Ellman's method
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.83 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4083836 | — | — | 1 | 6.40 |
| CHEMBL4064374 | — | — | 1 | 5.75 |
| CHEMBL4065398 | — | — | 1 | 5.57 |
| CHEMBL4073457 | — | — | 1 | 5.44 |
| CHEMBL4069293 | — | — | 1 | 5.43 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.36 |
| CHEMBL4094097 | — | — | 1 | 5.07 |
| CHEMBL4090338 | — | — | 1 | 5.02 |
| CHEMBL4084007 | — | — | 1 | 4.99 |
| CHEMBL4094559 | — | — | 1 | 4.95 |
| CHEMBL4091608 | — | — | 1 | 4.93 |
| CHEMBL4094660 | — | — | 1 | 4.91 |
| CHEMBL4087905 | — | — | 1 | 4.90 |
| CHEMBL4078982 | — | — | 1 | 4.83 |
| CHEMBL4099350 | — | — | 1 | 4.70 |
| CHEMBL4062293 | — | — | 1 | 4.69 |
| CHEMBL4096153 | — | — | 1 | 4.67 |
| CHEMBL3235456 | — | — | 1 | 4.64 |
| CHEMBL4095608 | — | — | 1 | 4.64 |
| CHEMBL4063824 | — | — | 1 | 4.62 |
| CHEMBL4092092 | — | — | 1 | 4.61 |
| CHEMBL4101838 | — | — | 1 | 4.61 |
| CHEMBL4102298 | — | — | 1 | 4.57 |
| CHEMBL4074011 | — | — | 1 | 4.53 |
| CHEMBL4084335 | — | — | 1 | 4.53 |
| CHEMBL4068237 | — | — | 1 | 4.52 |
| CHEMBL4103245 | — | — | 1 | 4.50 |
| CHEMBL4080020 | — | — | 1 | 4.50 |
| CHEMBL4074152 | — | — | 1 | 4.49 |
| CHEMBL4059592 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4083836 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4064374 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4065398 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4073457 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4069293 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL4094097 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4090338 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4084007 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4094559 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4091608 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4094660 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4087905 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL4078982 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4099350 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL4062293 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL4096153 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL3235456 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL4095608 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL4063824 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4092092 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL4101838 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL4102298 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4074011 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL4084335 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL4068237 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL4103245 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL4080020 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL4074152 | — | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL4059592 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL4078101 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4098050 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4086828 | — | IC50 | = | 44600.0 | nM | 4.35 |
| CHEMBL4072417 | — | IC50 | = | 48200.0 | nM | 4.32 |