Assay Detail
Binding
CHEMBL4035443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.37 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.47 |
| CHEMBL4073457 | — | — | 1 | 6.52 |
| CHEMBL4101838 | — | — | 1 | 6.00 |
| CHEMBL4078101 | — | — | 1 | 5.96 |
| CHEMBL4083836 | — | — | 1 | 5.92 |
| CHEMBL4094097 | — | — | 1 | 5.89 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 5.67 |
| CHEMBL4074011 | — | — | 1 | 5.62 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.50 |
| CHEMBL4091608 | — | — | 1 | 5.47 |
| CHEMBL4094559 | — | — | 1 | 5.34 |
| CHEMBL4094660 | — | — | 1 | 5.31 |
| CHEMBL4092092 | — | — | 1 | 5.27 |
| CHEMBL4072417 | — | — | 1 | 5.25 |
| CHEMBL4063824 | — | — | 1 | 5.24 |
| CHEMBL4099350 | — | — | 1 | 5.21 |
| CHEMBL4059592 | — | — | 1 | 5.18 |
| CHEMBL4064374 | — | — | 1 | 5.17 |
| CHEMBL4098050 | — | — | 1 | 5.16 |
| CHEMBL4080020 | — | — | 1 | 5.13 |
| CHEMBL4090338 | — | — | 1 | 5.11 |
| CHEMBL4065398 | — | — | 1 | 5.09 |
| CHEMBL4062293 | — | — | 1 | 5.08 |
| CHEMBL4103245 | — | — | 1 | 5.08 |
| CHEMBL4087905 | — | — | 1 | 5.07 |
| CHEMBL4084335 | — | — | 1 | 5.05 |
| CHEMBL4068237 | — | — | 1 | 5.05 |
| CHEMBL4102298 | — | — | 1 | 5.03 |
| CHEMBL4074152 | — | — | 1 | 5.03 |
| CHEMBL4084007 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4073457 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4101838 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4078101 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4083836 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4094097 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL887 | RASAGILINE | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL4074011 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL4091608 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4094559 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4094660 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4092092 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4072417 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4063824 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4099350 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4059592 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4064374 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4098050 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4080020 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4090338 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4065398 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4062293 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4103245 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4087905 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4084335 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4068237 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4102298 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4084007 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4074152 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4095608 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4096153 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4078982 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4086828 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3235456 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4069293 | — | IC50 | = | 14300.0 | nM | 4.84 |