Assay Detail
Binding
CHEMBL4035520
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Binding affinity to CK2alpha (unknown origin) by ITC
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 4.18 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070389 | — | — | 1 | 6.50 |
| CHEMBL4086439 | — | — | 1 | 5.79 |
| CHEMBL1161012 | — | — | 1 | 4.24 |
| CHEMBL4089903 | — | — | 1 | 3.57 |
| CHEMBL4105345 | — | — | 1 | 3.52 |
| CHEMBL4082041 | — | — | 1 | 3.30 |
| CHEMBL4061844 | — | — | 1 | 3.28 |
| CHEMBL4100054 | — | — | 1 | 3.20 |
| CHEMBL307782 | 3-AMINOBENZOIC ACID | — | 1 | - |
| CHEMBL4088836 | — | — | 1 | - |
| CHEMBL4104331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070389 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL4086439 | — | Kd | = | 1640.0 | nM | 5.79 |
| CHEMBL1161012 | — | Kd | = | 58000.0 | nM | 4.24 |
| CHEMBL4089903 | — | Kd | = | 270000.0 | nM | 3.57 |
| CHEMBL4105345 | — | Kd | = | 300000.0 | nM | 3.52 |
| CHEMBL4082041 | — | Kd | = | 500000.0 | nM | 3.30 |
| CHEMBL4061844 | — | Kd | = | 520000.0 | nM | 3.28 |
| CHEMBL4100054 | — | Kd | = | 629000.0 | nM | 3.20 |
| CHEMBL307782 | 3-AMINOBENZOIC ACID | Kd | > | 500000.0 | nM | - |
| CHEMBL4088836 | — | Kd | = | 250000.0 | nM | - |
| CHEMBL4104331 | — | Kd | = | 250000.0 | nM | - |