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Assay Detail

CHEMBL4035525

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Binding
Inhibition of CK2alpha/beta (unknown origin) expressed in Escherichia coli BL21(DE3) using RRRADDSDDDD as substrate after 40 mins by ADP-Glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Casein kinase II alpha/beta (CHEMBL3038477)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
De Fusco C, Brear P, Iegre J, Georgiou KH, Sore HF, Hyvönen M, Spring DR.
Bioorg Med Chem (2017) 25 : 3471 -3482
PubMed 28495381 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.17 6.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4070389 1 6.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4070389 IC50 = 670.0 nM 6.17