Assay Detail
Binding
CHEMBL4036032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged IDO1 expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of kynurenine production using L-tryptophan as substrate after 1 hr by fluorescence assay relative to control
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and preliminary structure-activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.95 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079351 | — | — | 1 | 5.56 |
| CHEMBL4062551 | — | — | 1 | 5.28 |
| CHEMBL4072215 | — | — | 1 | 5.01 |
| CHEMBL4101667 | — | — | 1 | 4.98 |
| CHEMBL4063611 | — | — | 1 | 4.97 |
| CHEMBL4074982 | — | — | 1 | 4.83 |
| CHEMBL571209 | INDOXIMOD | 2.0 | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079351 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4062551 | — | IC50 | = | 5255.0 | nM | 5.28 |
| CHEMBL4072215 | — | IC50 | = | 9784.0 | nM | 5.01 |
| CHEMBL4101667 | — | IC50 | = | 10390.0 | nM | 4.98 |
| CHEMBL4063611 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4074982 | — | IC50 | = | 14970.0 | nM | 4.83 |
| CHEMBL571209 | INDOXIMOD | IC50 | = | 95600.0 | nM | 4.02 |