Assay Detail
Binding
CHEMBL4036033
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Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells using L-tryptophan as substrate after 24 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and preliminary structure-activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.90 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079351 | — | — | 1 | 5.04 |
| CHEMBL4062551 | — | — | 1 | 5.01 |
| CHEMBL4072215 | — | — | 1 | 4.90 |
| CHEMBL4101667 | — | — | 1 | 4.88 |
| CHEMBL4063611 | — | — | 1 | 4.82 |
| CHEMBL4074982 | — | — | 1 | 4.76 |
| CHEMBL571209 | INDOXIMOD | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079351 | — | EC50 | = | 9171.0 | nM | 5.04 |
| CHEMBL4062551 | — | EC50 | = | 9703.0 | nM | 5.01 |
| CHEMBL4072215 | — | EC50 | = | 12520.0 | nM | 4.90 |
| CHEMBL4101667 | — | EC50 | = | 13260.0 | nM | 4.88 |
| CHEMBL4063611 | — | EC50 | = | 15310.0 | nM | 4.82 |
| CHEMBL4074982 | — | EC50 | = | 17540.0 | nM | 4.76 |
| CHEMBL571209 | INDOXIMOD | EC50 | = | 110000.0 | nM | - |