Assay Detail
ADMET
CHEMBL4036365
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human cytosolic carbonic anhydrase 2 expressed in Escherichia coli pretreated for 15 mins prior to testing by stopped-flow assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.51 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL4104834 | — | — | 1 | 7.57 |
| CHEMBL4097126 | — | — | 1 | 7.50 |
| CHEMBL4069928 | — | — | 1 | 6.40 |
| CHEMBL4099555 | — | — | 1 | 6.38 |
| CHEMBL4072614 | — | — | 1 | 6.37 |
| CHEMBL4081547 | — | — | 1 | 6.26 |
| CHEMBL4061260 | — | — | 1 | 6.21 |
| CHEMBL4064015 | — | — | 1 | 6.16 |
| CHEMBL4070963 | — | — | 1 | 6.13 |
| CHEMBL4093328 | — | — | 1 | 6.11 |
| CHEMBL4089415 | — | — | 1 | 6.07 |
| CHEMBL4080604 | — | — | 1 | 6.05 |
| CHEMBL4091812 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL4104834 | — | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL4097126 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL4069928 | — | Ki | = | 399.4 | nM | 6.40 |
| CHEMBL4099555 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL4072614 | — | Ki | = | 425.6 | nM | 6.37 |
| CHEMBL4081547 | — | Ki | = | 551.0 | nM | 6.26 |
| CHEMBL4061260 | — | Ki | = | 616.0 | nM | 6.21 |
| CHEMBL4064015 | — | Ki | = | 687.0 | nM | 6.16 |
| CHEMBL4070963 | — | Ki | = | 735.0 | nM | 6.13 |
| CHEMBL4093328 | — | Ki | = | 782.1 | nM | 6.11 |
| CHEMBL4089415 | — | Ki | = | 851.0 | nM | 6.07 |
| CHEMBL4080604 | — | Ki | = | 897.0 | nM | 6.05 |
| CHEMBL4091812 | — | Ki | = | 936.0 | nM | 6.03 |