Assay Detail
Binding
CHEMBL4036366
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Inhibition of recombinant human membrane bound carbonic anhydrase 9 expressed in Escherichia coli pretreated for 15 mins prior to testing by stopped-flow assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.47 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072614 | — | — | 1 | 7.88 |
| CHEMBL4069928 | — | — | 1 | 7.78 |
| CHEMBL4097126 | — | — | 1 | 7.71 |
| CHEMBL4104834 | — | — | 1 | 7.68 |
| CHEMBL4093328 | — | — | 1 | 7.67 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL4080604 | — | — | 1 | 7.46 |
| CHEMBL4081547 | — | — | 1 | 7.41 |
| CHEMBL4099555 | — | — | 1 | 7.34 |
| CHEMBL4061260 | — | — | 1 | 7.27 |
| CHEMBL4064015 | — | — | 1 | 7.24 |
| CHEMBL4070963 | — | — | 1 | 7.21 |
| CHEMBL4089415 | — | — | 1 | 7.19 |
| CHEMBL4091812 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072614 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL4069928 | — | Ki | = | 16.8 | nM | 7.78 |
| CHEMBL4097126 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL4104834 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL4093328 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4080604 | — | Ki | = | 34.4 | nM | 7.46 |
| CHEMBL4081547 | — | Ki | = | 38.8 | nM | 7.41 |
| CHEMBL4099555 | — | Ki | = | 45.7 | nM | 7.34 |
| CHEMBL4061260 | — | Ki | = | 54.2 | nM | 7.27 |
| CHEMBL4064015 | — | Ki | = | 58.1 | nM | 7.24 |
| CHEMBL4070963 | — | Ki | = | 62.3 | nM | 7.21 |
| CHEMBL4089415 | — | Ki | = | 64.8 | nM | 7.19 |
| CHEMBL4091812 | — | Ki | = | 66.3 | nM | 7.18 |