Assay Detail
Functional
CHEMBL4036497
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Cytotoxic activity against human SGC7901 cells incubated for 48 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SGC-7901 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 3- and 29-substituted celastrol derivatives and structure-activity relationship studies of their cytotoxic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.05 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3920061 | — | — | 1 | 6.62 |
| CHEMBL3417313 | — | — | 1 | 6.62 |
| CHEMBL4086826 | — | — | 1 | 6.52 |
| CHEMBL4086626 | — | — | 1 | 6.51 |
| CHEMBL1170915 | — | — | 1 | 6.51 |
| CHEMBL4088297 | — | — | 1 | 6.48 |
| CHEMBL4073434 | — | — | 1 | 6.44 |
| CHEMBL4079406 | — | — | 1 | 6.34 |
| CHEMBL1172284 | — | — | 1 | 6.33 |
| CHEMBL3892041 | — | — | 1 | 6.33 |
| CHEMBL4076216 | — | — | 1 | 6.29 |
| CHEMBL54804 | PRISTIMERIN | — | 1 | 6.20 |
| CHEMBL4077984 | — | — | 1 | 6.17 |
| CHEMBL4067422 | — | — | 1 | 6.16 |
| CHEMBL4076720 | — | — | 1 | 6.14 |
| CHEMBL4094156 | — | — | 1 | 6.09 |
| CHEMBL4093600 | — | — | 1 | 6.09 |
| CHEMBL301982 | CELASTROL | — | 1 | 6.06 |
| CHEMBL4066575 | — | — | 1 | 5.89 |
| CHEMBL4067027 | — | — | 1 | 5.80 |
| CHEMBL4090657 | — | — | 1 | 5.75 |
| CHEMBL4063367 | — | — | 1 | 5.54 |
| CHEMBL4103958 | — | — | 1 | 5.52 |
| CHEMBL4077142 | — | — | 1 | 5.44 |
| CHEMBL4076951 | — | — | 1 | 5.37 |
| CHEMBL4062696 | — | — | 1 | 5.33 |
| CHEMBL4069069 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3920061 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3417313 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4086826 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4086626 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1170915 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4088297 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4073434 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4079406 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1172284 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3892041 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4076216 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4077984 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4067422 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4076720 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4094156 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4093600 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL301982 | CELASTROL | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4066575 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4067027 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4090657 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4063367 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL4103958 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL4077142 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL4076951 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL4062696 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4069069 | — | IC50 | = | 11720.0 | nM | 4.93 |