Assay Detail
Functional
CHEMBL4036498
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Cytotoxic activity against human HeLa cells incubated for 48 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 3- and 29-substituted celastrol derivatives and structure-activity relationship studies of their cytotoxic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.96 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088297 | — | — | 1 | 6.51 |
| CHEMBL54804 | PRISTIMERIN | — | 1 | 6.50 |
| CHEMBL4073434 | — | — | 1 | 6.44 |
| CHEMBL4076216 | — | — | 1 | 6.39 |
| CHEMBL3920061 | — | — | 1 | 6.39 |
| CHEMBL4086626 | — | — | 1 | 6.38 |
| CHEMBL1170915 | — | — | 1 | 6.34 |
| CHEMBL4079406 | — | — | 1 | 6.25 |
| CHEMBL4077984 | — | — | 1 | 6.21 |
| CHEMBL4076720 | — | — | 1 | 6.10 |
| CHEMBL3417313 | — | — | 1 | 6.08 |
| CHEMBL301982 | CELASTROL | — | 1 | 6.08 |
| CHEMBL4094156 | — | — | 1 | 6.06 |
| CHEMBL4067422 | — | — | 1 | 5.98 |
| CHEMBL4086826 | — | — | 1 | 5.95 |
| CHEMBL4093600 | — | — | 1 | 5.88 |
| CHEMBL4077142 | — | — | 1 | 5.87 |
| CHEMBL1172284 | — | — | 1 | 5.86 |
| CHEMBL4090657 | — | — | 1 | 5.81 |
| CHEMBL4063367 | — | — | 1 | 5.80 |
| CHEMBL3892041 | — | — | 1 | 5.76 |
| CHEMBL4067027 | — | — | 1 | 5.74 |
| CHEMBL4066575 | — | — | 1 | 5.64 |
| CHEMBL4103958 | — | — | 1 | 5.55 |
| CHEMBL4062696 | — | — | 1 | 5.37 |
| CHEMBL4076951 | — | — | 1 | 5.20 |
| CHEMBL4069069 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088297 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4073434 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4076216 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3920061 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4086626 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1170915 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4079406 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4077984 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4076720 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3417313 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL301982 | CELASTROL | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4094156 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4067422 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4086826 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4093600 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4077142 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL1172284 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4090657 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4063367 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL3892041 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4067027 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL4066575 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4103958 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL4062696 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL4076951 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL4069069 | — | IC50 | = | 18010.0 | nM | 4.74 |