Assay Detail
Functional
CHEMBL4036656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 5 days by Cell-titer Glo reagent based assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 7.58 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3913732 | — | — | 1 | 8.85 |
| CHEMBL4060799 | — | — | 1 | 8.64 |
| CHEMBL3943749 | — | — | 1 | 8.55 |
| CHEMBL4089003 | — | — | 1 | 8.49 |
| CHEMBL4096471 | — | — | 1 | 8.41 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 8.36 |
| CHEMBL4077485 | — | — | 1 | 8.25 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 8.24 |
| CHEMBL4076064 | — | — | 1 | 8.19 |
| CHEMBL3926822 | — | — | 1 | 8.19 |
| CHEMBL4105475 | — | — | 1 | 8.18 |
| CHEMBL4083505 | — | — | 1 | 8.10 |
| CHEMBL3922276 | — | — | 1 | 8.09 |
| CHEMBL3908312 | — | — | 1 | 8.08 |
| CHEMBL3960317 | — | — | 1 | 8.08 |
| CHEMBL3941284 | — | — | 1 | 8.00 |
| CHEMBL3984857 | — | — | 1 | 7.85 |
| CHEMBL4086819 | — | — | 1 | 7.82 |
| CHEMBL4077254 | — | — | 1 | 7.77 |
| CHEMBL3904786 | — | — | 1 | 7.77 |
| CHEMBL3896390 | — | — | 1 | 7.75 |
| CHEMBL4062838 | — | — | 1 | 7.72 |
| CHEMBL3892230 | — | — | 1 | 7.68 |
| CHEMBL3938019 | — | — | 1 | 7.68 |
| CHEMBL4082366 | — | — | 1 | 7.62 |
| CHEMBL4076641 | — | — | 1 | 7.52 |
| CHEMBL3940058 | — | — | 1 | 7.50 |
| CHEMBL3950120 | — | — | 1 | 7.42 |
| CHEMBL3975643 | — | — | 1 | 7.32 |
| CHEMBL3929298 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3913732 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4060799 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3943749 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4089003 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4096471 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL17289 | CHS-828 | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4077485 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4076064 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3926822 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4105475 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4083505 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3922276 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3908312 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL3960317 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL3941284 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3984857 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4086819 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4077254 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3904786 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3896390 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4062838 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3892230 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3938019 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4082366 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4076641 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3940058 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3950120 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3975643 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3929298 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3899179 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3930840 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3974537 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3907814 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3953911 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3918436 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3937583 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4099778 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4081887 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3890237 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3949149 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3715249 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3972460 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3890168 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3925932 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4062656 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2419508 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4090863 | — | IC50 | > | 12500.0 | nM | - |