Assay Detail
Functional
CHEMBL4036692
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Inhibition of alpha-MSH-stimulated melanogenesis in mouse B16 cells assessed as reduction in melanin formation
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.43 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097588 | — | — | 1 | 6.70 |
| CHEMBL4104681 | — | — | 1 | 6.00 |
| CHEMBL4064735 | — | — | 1 | 5.92 |
| CHEMBL4088936 | — | — | 1 | 5.85 |
| CHEMBL4095508 | — | — | 1 | 5.85 |
| CHEMBL4088309 | — | — | 1 | 5.85 |
| CHEMBL1163788 | — | — | 1 | 5.85 |
| CHEMBL4067038 | — | — | 1 | 5.80 |
| CHEMBL4067642 | — | — | 1 | 5.75 |
| CHEMBL4077996 | — | — | 1 | 5.75 |
| CHEMBL1163787 | — | — | 1 | 5.72 |
| CHEMBL4077326 | — | — | 1 | 5.55 |
| CHEMBL4095416 | — | — | 1 | 5.52 |
| CHEMBL4076921 | — | — | 1 | 5.47 |
| CHEMBL4096036 | — | — | 1 | 5.43 |
| CHEMBL4076549 | — | — | 1 | 5.24 |
| CHEMBL4089973 | — | — | 1 | 5.22 |
| CHEMBL4061276 | — | — | 1 | 5.21 |
| CHEMBL4064655 | — | — | 1 | 5.19 |
| CHEMBL4076218 | — | — | 1 | 5.16 |
| CHEMBL472582 | — | — | 1 | 5.16 |
| CHEMBL275362 | — | — | 1 | 5.12 |
| CHEMBL67291 | — | — | 1 | 5.10 |
| CHEMBL4076658 | — | — | 1 | 4.70 |
| CHEMBL67444 | — | — | 1 | 4.62 |
| CHEMBL4093983 | — | — | 1 | 4.52 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.24 |
| CHEMBL4061624 | — | — | 1 | - |
| CHEMBL4076071 | — | — | 1 | - |
| CHEMBL416955 | CHLOROGENIC ACID METHYL ESTER | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097588 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4104681 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4064735 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4088936 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4095508 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4088309 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1163788 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4067038 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4067642 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4077996 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1163787 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4077326 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4095416 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4076921 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4096036 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4076549 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4089973 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4061276 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4064655 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4076218 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL472582 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL275362 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL67291 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4076658 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL67444 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4093983 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4061624 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4076071 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL416955 | CHLOROGENIC ACID METHYL ESTER | IC50 | > | 40000.0 | nM | - |
| CHEMBL33541 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL232202 | ARBUTIN | IC50 | = | 400000.0 | nM | - |