Assay Detail

CHEMBL4037079

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Functional

Cytotoxicity against human MCF7 cells assessed as reduction in protein synthesis

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

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Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Autocuration

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.

Talele TT.
J Med Chem (2018) 61 : 2166 -2210
PubMed 28850227 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.06	9.06

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL46286	OMACETAXINE MEPESUCCINATE	4.0	1	9.06

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL46286	OMACETAXINE MEPESUCCINATE	IC50	=	0.87	nM	9.06