Assay Detail
Functional
CHEMBL4037083
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Cytotoxicity against human 1A9 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.82 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 10.22 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.45 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.43 |
| CHEMBL1201752 | IXABEPILONE | 4.0 | 1 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 3.55 | nM | 8.45 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.71 | nM | 8.43 |
| CHEMBL1201752 | IXABEPILONE | IC50 | = | 6.65 | nM | 8.18 |