Assay Detail
Functional
CHEMBL4037381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KB cells after 72 hrs by sulforhodamine B assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural Modification of Natural Product Tanshinone I Leading to Discovery of Novel Nitrogen-Enriched Derivatives with Enhanced Anticancer Profile and Improved Drug-like Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.67 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 9.14 |
| CHEMBL4077247 | — | — | 1 | 6.92 |
| CHEMBL4092979 | — | — | 1 | 6.47 |
| CHEMBL4103883 | — | — | 1 | 6.15 |
| CHEMBL4065313 | — | — | 1 | 6.06 |
| CHEMBL4089600 | — | — | 1 | 5.96 |
| CHEMBL4076238 | — | — | 1 | 5.95 |
| CHEMBL4061520 | — | — | 1 | 5.90 |
| CHEMBL4101708 | — | — | 1 | 5.82 |
| CHEMBL4062895 | — | — | 1 | 5.81 |
| CHEMBL4093287 | — | — | 1 | 5.80 |
| CHEMBL4075026 | — | — | 1 | 5.79 |
| CHEMBL4079929 | — | — | 1 | 5.79 |
| CHEMBL4076305 | — | — | 1 | 5.66 |
| CHEMBL4068862 | — | — | 1 | 5.64 |
| CHEMBL4096437 | — | — | 1 | 5.58 |
| CHEMBL4104166 | — | — | 1 | 5.58 |
| CHEMBL4083037 | — | — | 1 | 5.57 |
| CHEMBL4070130 | — | — | 1 | 5.49 |
| CHEMBL4085955 | — | — | 1 | 5.47 |
| CHEMBL4103168 | — | — | 1 | 5.42 |
| CHEMBL4090826 | — | — | 1 | 5.42 |
| CHEMBL4096125 | — | — | 1 | 5.39 |
| CHEMBL4071514 | — | — | 1 | 5.30 |
| CHEMBL4101017 | — | — | 1 | 5.28 |
| CHEMBL363535 | TANSHINONE I | — | 1 | 5.23 |
| CHEMBL4061471 | — | — | 1 | 5.09 |
| CHEMBL4082047 | — | — | 1 | 5.03 |
| CHEMBL4098549 | — | — | 1 | 5.01 |
| CHEMBL4077566 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL4077247 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4092979 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4103883 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4065313 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4089600 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4076238 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4061520 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4101708 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4062895 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4093287 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4075026 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4079929 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4076305 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4068862 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4096437 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL4104166 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL4083037 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL4070130 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4085955 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4090826 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4103168 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL4096125 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL4071514 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL4101017 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL363535 | TANSHINONE I | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL4061471 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL4082047 | — | IC50 | = | 9430.0 | nM | 5.03 |
| CHEMBL4098549 | — | IC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL4077566 | — | IC50 | = | 10380.0 | nM | 4.98 |
| CHEMBL4078071 | — | IC50 | = | 13840.0 | nM | 4.86 |
| CHEMBL4067138 | — | IC50 | = | 15270.0 | nM | 4.82 |
| CHEMBL4085237 | — | IC50 | = | 17240.0 | nM | 4.76 |
| CHEMBL4087807 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4060158 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4075080 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4088400 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4103262 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4085332 | — | IC50 | > | 20000.0 | nM | - |