Assay Detail
Functional
CHEMBL4037382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KB/VCR cells after 72 hrs by sulforhodamine B assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB/VCR |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Modification of Natural Product Tanshinone I Leading to Discovery of Novel Nitrogen-Enriched Derivatives with Enhanced Anticancer Profile and Improved Drug-like Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.67 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4077247 | — | — | 1 | 6.48 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 6.45 |
| CHEMBL4089600 | — | — | 1 | 6.29 |
| CHEMBL4103883 | — | — | 1 | 6.04 |
| CHEMBL4061520 | — | — | 1 | 6.04 |
| CHEMBL4101708 | — | — | 1 | 5.99 |
| CHEMBL4062895 | — | — | 1 | 5.96 |
| CHEMBL4079929 | — | — | 1 | 5.91 |
| CHEMBL4075026 | — | — | 1 | 5.84 |
| CHEMBL4065313 | — | — | 1 | 5.83 |
| CHEMBL4076238 | — | — | 1 | 5.82 |
| CHEMBL4068862 | — | — | 1 | 5.81 |
| CHEMBL4103168 | — | — | 1 | 5.78 |
| CHEMBL4096437 | — | — | 1 | 5.77 |
| CHEMBL4092979 | — | — | 1 | 5.76 |
| CHEMBL4093287 | — | — | 1 | 5.75 |
| CHEMBL4076305 | — | — | 1 | 5.70 |
| CHEMBL4067138 | — | — | 1 | 5.70 |
| CHEMBL4104166 | — | — | 1 | 5.62 |
| CHEMBL4071514 | — | — | 1 | 5.62 |
| CHEMBL4096125 | — | — | 1 | 5.61 |
| CHEMBL4085955 | — | — | 1 | 5.58 |
| CHEMBL4070130 | — | — | 1 | 5.53 |
| CHEMBL4077566 | — | — | 1 | 5.45 |
| CHEMBL4090826 | — | — | 1 | 5.42 |
| CHEMBL363535 | TANSHINONE I | — | 1 | 5.36 |
| CHEMBL4083037 | — | — | 1 | 5.36 |
| CHEMBL4098549 | — | — | 1 | 5.32 |
| CHEMBL4078071 | — | — | 1 | 5.29 |
| CHEMBL4061471 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4077247 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 357.51 | nM | 6.45 |
| CHEMBL4089600 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4103883 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4061520 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4101708 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4062895 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4079929 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4075026 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4065313 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4076238 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4068862 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4103168 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL4096437 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4092979 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4093287 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4076305 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL4067138 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4071514 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL4104166 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL4096125 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4085955 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL4070130 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4077566 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL4090826 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL363535 | TANSHINONE I | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4083037 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL4098549 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL4078071 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL4061471 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL4085237 | — | IC50 | = | 10070.0 | nM | 5.00 |
| CHEMBL4082047 | — | IC50 | = | 10880.0 | nM | 4.96 |
| CHEMBL4101017 | — | IC50 | = | 13120.0 | nM | 4.88 |
| CHEMBL4085332 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4103262 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4088400 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4075080 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4087807 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4060158 | — | IC50 | > | 20000.0 | nM | - |