Assay Detail
Binding
CHEMBL4037437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CHK1 (unknown origin)
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.44 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 8.30 |
| CHEMBL4059912 | — | — | 1 | 8.22 |
| CHEMBL4079910 | — | — | 1 | 8.22 |
| CHEMBL4066751 | — | — | 1 | 8.22 |
| CHEMBL487273 | — | — | 1 | 8.15 |
| CHEMBL1287920 | — | — | 1 | 8.15 |
| CHEMBL4067770 | — | — | 1 | 8.05 |
| CHEMBL4082801 | — | — | 1 | 8.00 |
| CHEMBL4098878 | — | — | 1 | 7.92 |
| CHEMBL4093952 | — | — | 1 | 7.92 |
| CHEMBL4071952 | — | — | 1 | 7.85 |
| CHEMBL4097937 | — | — | 1 | 7.82 |
| CHEMBL4105353 | — | — | 1 | 7.82 |
| CHEMBL4094277 | — | — | 1 | 7.70 |
| CHEMBL4104102 | — | — | 1 | 7.68 |
| CHEMBL4088986 | — | — | 1 | 7.64 |
| CHEMBL4104408 | — | — | 1 | 7.62 |
| CHEMBL4097424 | — | — | 1 | 7.60 |
| CHEMBL4096683 | — | — | 1 | 7.51 |
| CHEMBL4079391 | — | — | 1 | 7.46 |
| CHEMBL4068572 | — | — | 1 | 7.25 |
| CHEMBL4100776 | — | — | 1 | 7.16 |
| CHEMBL4076939 | — | — | 1 | 7.10 |
| CHEMBL4066399 | — | — | 1 | 7.08 |
| CHEMBL4089699 | — | — | 1 | 7.08 |
| CHEMBL4081827 | — | — | 1 | 6.85 |
| CHEMBL4078664 | — | — | 1 | 6.82 |
| CHEMBL4081097 | — | — | 1 | 6.48 |
| CHEMBL4098331 | — | — | 1 | 6.18 |
| CHEMBL4082386 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041933 | AZD-7762 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4059912 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4079910 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4066751 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL487273 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1287920 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4067770 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4082801 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4098878 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4093952 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4071952 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4097937 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4105353 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4094277 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4104102 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4088986 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4104408 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4097424 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4096683 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4079391 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4068572 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4100776 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4076939 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4066399 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4089699 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4081827 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4078664 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4081097 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4098331 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4082386 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4083348 | — | IC50 | = | 6800.0 | nM | 5.17 |