Assay Detail
Binding
CHEMBL4037438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by patch clamp assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.19 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098331 | — | — | 1 | 5.68 |
| CHEMBL4079391 | — | — | 1 | 5.62 |
| CHEMBL4104102 | — | — | 1 | 5.61 |
| CHEMBL4097424 | — | — | 1 | 5.57 |
| CHEMBL4089699 | — | — | 1 | 5.42 |
| CHEMBL4105353 | — | — | 1 | 5.39 |
| CHEMBL4068572 | — | — | 1 | 5.31 |
| CHEMBL4100776 | — | — | 1 | 5.23 |
| CHEMBL4088986 | — | — | 1 | 5.17 |
| CHEMBL4067770 | — | — | 1 | 5.11 |
| CHEMBL4093952 | — | — | 1 | 5.08 |
| CHEMBL4096683 | — | — | 1 | 4.94 |
| CHEMBL4098878 | — | — | 1 | 4.85 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 4.82 |
| CHEMBL1287920 | — | — | 1 | 4.71 |
| CHEMBL4079910 | — | — | 1 | 4.55 |
| CHEMBL4081097 | — | — | 1 | - |
| CHEMBL4076939 | — | — | 1 | - |
| CHEMBL4081827 | — | — | 1 | - |
| CHEMBL4059912 | — | — | 1 | - |
| CHEMBL4097937 | — | — | 1 | - |
| CHEMBL4082801 | — | — | 1 | - |
| CHEMBL487273 | — | — | 1 | - |
| CHEMBL4082386 | — | — | 1 | - |
| CHEMBL4083348 | — | — | 1 | - |
| CHEMBL4066399 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098331 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4079391 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4104102 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4097424 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4089699 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4105353 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4068572 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4100776 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4088986 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4067770 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4093952 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4096683 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4098878 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1287920 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL4079910 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4081097 | — | IC50 | - | — | - | |
| CHEMBL4076939 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL4081827 | — | IC50 | - | — | - | |
| CHEMBL4059912 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL4097937 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4082801 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL487273 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL4082386 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL4083348 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL4066399 | — | IC50 | > | 31600.0 | nM | - |