Assay Detail
Binding
CHEMBL4037928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC after 60 mins by cellular thermal shift assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Oxidized purine nucleoside triphosphate hydrolase (CHEMBL3708265) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.68 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091768 | — | — | 1 | 8.70 |
| CHEMBL4073623 | — | — | 1 | 8.70 |
| CHEMBL4094252 | — | — | 1 | 8.00 |
| CHEMBL4061204 | — | — | 1 | 7.20 |
| CHEMBL3782004 | — | — | 1 | 6.90 |
| CHEMBL4066892 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091768 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4073623 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4094252 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4061204 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL3782004 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4066892 | — | EC50 | = | 251.19 | nM | 6.60 |