Assay Detail
Binding
CHEMBL4037932
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Binding to C-terminal His6-tagged human MD2 expressed in Pichia pastoris GS115 by surface plasmon resonance assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 4.80 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100044 | — | — | 1 | 5.52 |
| CHEMBL4070714 | — | — | 1 | 4.85 |
| CHEMBL4069693 | — | — | 1 | 4.66 |
| CHEMBL4091601 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100044 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL4070714 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL4069693 | — | Kd | = | 22000.0 | nM | 4.66 |
| CHEMBL4091601 | — | Kd | = | 67000.0 | nM | 4.17 |