Assay Detail
Binding
CHEMBL4038129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.39 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093698 | — | — | 1 | 8.00 |
| CHEMBL4079260 | — | — | 1 | 7.08 |
| CHEMBL4059991 | — | — | 1 | 5.84 |
| CHEMBL4070056 | — | — | 1 | 5.58 |
| CHEMBL4094403 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093698 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4079260 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL4059991 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL4070056 | — | Ki | = | 2650.0 | nM | 5.58 |
| CHEMBL4094403 | — | Ki | = | 3400.0 | nM | 5.47 |