Assay Detail
Functional
CHEMBL4038481
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Inhibition of RANKL-induced C57BL/6 mouse bone marrow monocytes differentiation into osteoclasts after 6 days in presence of M-CSF by tartrate-resistant acid phosphatase staining based assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Bone marrow monocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of heterocyclic ring-fused tricyclic diterpene analogs as novel inhibitors of RANKL-induced osteoclastogenesis and bone resorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.30 | 7.40 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084109 | — | — | 2 | 7.40 |
| CHEMBL4104604 | — | — | 1 | 6.48 |
| CHEMBL201515 | MASLINIC ACID | — | 1 | 6.20 |
| CHEMBL4092446 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084109 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4104604 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL201515 | MASLINIC ACID | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4092446 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4084109 | — | Inhibition | - | % | - |