Assay Detail
ADMET
CHEMBL4038534
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Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel podophyllotoxin-NSAIDs conjugates as multifunctional anti-MDR agents against resistant human hepatocellular carcinoma Bel-7402/5-FU cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.01 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.66 |
| CHEMBL4095266 | — | — | 1 | 7.05 |
| CHEMBL4105437 | — | — | 1 | 5.73 |
| CHEMBL4087564 | — | — | 1 | 5.13 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.49 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4095266 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4105437 | — | IC50 | = | 1858.0 | nM | 5.73 |
| CHEMBL4087564 | — | IC50 | = | 7385.0 | nM | 5.13 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 32546.0 | nM | 4.49 |
| CHEMBL521 | IBUPROFEN | IC50 | > | 100000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL25 | ASPIRIN | IC50 | > | 100000.0 | nM | - |