Assay Detail
Binding
CHEMBL4038748
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Displacement of [3H]U-69593 from recombinant human kappa opioid receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counter analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and characterization of opioid ligands based on cycle-in-macrocycle scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.09 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927270 | — | — | 1 | 8.63 |
| CHEMBL4083221 | — | — | 1 | 6.05 |
| CHEMBL4095366 | — | — | 1 | 5.33 |
| CHEMBL4085033 | — | — | 1 | 5.26 |
| CHEMBL4074931 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927270 | — | Ki | = | 2.36 | nM | 8.63 |
| CHEMBL4083221 | — | Ki | = | 884.0 | nM | 6.05 |
| CHEMBL4095366 | — | Ki | = | 4625.0 | nM | 5.33 |
| CHEMBL4085033 | — | Ki | = | 5461.0 | nM | 5.26 |
| CHEMBL4074931 | — | Ki | = | 6717.0 | nM | 5.17 |