Assay Detail
Binding
CHEMBL4039094
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Inhibition of BMP6/hemojuvelin signalling pathway in human HepG2 cells assessed as reduction in hepcidin mRNA expression
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and SAR studies of 3,6-disubstituted indazole derivatives as potent hepcidin production inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.12 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075033 | — | — | 1 | 7.07 |
| CHEMBL4085290 | — | — | 1 | 6.92 |
| CHEMBL4063674 | — | — | 1 | 6.89 |
| CHEMBL4064594 | — | — | 1 | 6.80 |
| CHEMBL4092281 | — | — | 1 | 6.48 |
| CHEMBL260163 | — | — | 1 | 6.40 |
| CHEMBL4094750 | — | — | 1 | 6.38 |
| CHEMBL4095682 | — | — | 1 | 6.33 |
| CHEMBL4074249 | — | — | 1 | 6.16 |
| CHEMBL4097163 | — | — | 1 | 6.03 |
| CHEMBL4079186 | — | — | 1 | 6.03 |
| CHEMBL4065626 | — | — | 1 | 6.01 |
| CHEMBL4089453 | — | — | 1 | 6.00 |
| CHEMBL4103442 | — | — | 1 | 5.96 |
| CHEMBL4087051 | — | — | 1 | 5.96 |
| CHEMBL4086759 | — | — | 1 | 5.85 |
| CHEMBL4069964 | — | — | 1 | 5.80 |
| CHEMBL4086141 | — | — | 1 | 5.51 |
| CHEMBL4066248 | — | — | 1 | 5.38 |
| CHEMBL4097069 | — | — | 1 | 5.35 |
| CHEMBL4094782 | — | — | 1 | 5.31 |
| CHEMBL4061296 | — | — | 1 | - |
| CHEMBL4076432 | — | — | 1 | - |
| CHEMBL106060 | — | — | 1 | - |
| CHEMBL4104870 | — | — | 1 | - |
| CHEMBL102936 | — | — | 1 | - |
| CHEMBL4067332 | — | — | 1 | - |
| CHEMBL4093822 | — | — | 1 | - |
| CHEMBL4070698 | — | — | 1 | - |
| CHEMBL4068327 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075033 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4085290 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4063674 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4064594 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4092281 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL260163 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4094750 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4095682 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4074249 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4097163 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4079186 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4065626 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4089453 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4103442 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4087051 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4086759 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4069964 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4086141 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4066248 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4097069 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4094782 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4061296 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4076432 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL106060 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4104870 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL102936 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4067332 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4093822 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4070698 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4068327 | — | IC50 | > | 30000.0 | nM | - |