Assay Detail
Binding
CHEMBL4039114
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by Amplex red dye based fluorescence assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.38 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4063580 | — | — | 1 | 6.10 |
| CHEMBL4088366 | — | — | 1 | 5.92 |
| CHEMBL468597 | — | — | 1 | 5.68 |
| CHEMBL4083895 | — | — | 1 | 5.39 |
| CHEMBL4098523 | — | — | 1 | 5.17 |
| CHEMBL466770 | — | — | 1 | 5.17 |
| CHEMBL4080504 | — | — | 1 | 5.17 |
| CHEMBL4079589 | — | — | 1 | 5.09 |
| CHEMBL4103844 | — | — | 1 | 5.08 |
| CHEMBL4075414 | — | — | 1 | 5.04 |
| CHEMBL4088315 | — | — | 1 | - |
| CHEMBL4103002 | — | — | 1 | - |
| CHEMBL4076750 | — | — | 1 | - |
| CHEMBL4060129 | — | — | 1 | - |
| CHEMBL4061133 | — | — | 1 | - |
| CHEMBL4083013 | — | — | 1 | - |
| CHEMBL4090801 | — | — | 1 | - |
| CHEMBL4104945 | — | — | 1 | - |
| CHEMBL4087091 | — | — | 1 | - |
| CHEMBL469024 | — | — | 1 | - |
| CHEMBL455782 | — | — | 1 | - |
| CHEMBL468852 | — | — | 1 | - |
| CHEMBL462630 | — | — | 1 | - |
| CHEMBL447729 | — | — | 1 | - |
| CHEMBL4083630 | — | — | 1 | - |
| CHEMBL4074238 | — | — | 1 | - |
| CHEMBL4069807 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4063580 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4088366 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL468597 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4083895 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4098523 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL466770 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4080504 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4079589 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4103844 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4075414 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4088315 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4103002 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4076750 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4060129 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4061133 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4083013 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4090801 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4104945 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4087091 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL469024 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL455782 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL468852 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL462630 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL447729 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4083630 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4074238 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4069807 | — | IC50 | > | 50000.0 | nM | - |