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Assay Detail

CHEMBL4040197

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HBV ayw1 infected in human HepG2(2.2.15) cells assessed as reduction in viral replication by measuring extracellular viral DNA copy number after 6 days by real-time qPCR method
ChEMBL ↗
36
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepatitis B virus
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis B virus (CHEMBL613497) ↗
Type ORGANISM
Organism Hepatitis B virus

Publication

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Luo M, Groaz E, Andrei G, Snoeck R, Kalkeri R, Ptak RG, Hartman T, Buckheit RW, Schols D, De Jonghe S, Herdewijn P.
J Med Chem (2017) 60 : 6220 -6238
PubMed 28682067 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC90 18 - -
EC50 18 5.95 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4070180 — — 2 8.00
CHEMBL141 LAMIVUDINE 4.0 2 7.70
CHEMBL4089642 — — 2 7.70
CHEMBL4099787 — — 2 6.89
CHEMBL93006 — — 2 6.31
CHEMBL329554 — — 2 6.23
CHEMBL4073327 — — 2 5.97
CHEMBL482465 — — 2 4.95
CHEMBL4081770 — — 2 4.55
CHEMBL4080837 — — 2 4.38
CHEMBL4078094 — — 2 4.37
CHEMBL4097362 — — 2 4.33
CHEMBL5314362 ENTECAVIR 4.0 2 -
CHEMBL4062343 — — 2 -
CHEMBL4082499 — — 2 -
CHEMBL519667 — — 2 -
CHEMBL270618 — — 2 -
CHEMBL2030736 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4070180 — EC50 = 10.0 nM 8.00
CHEMBL141 LAMIVUDINE EC50 = 20.0 nM 7.70
CHEMBL4089642 — EC50 = 20.0 nM 7.70
CHEMBL4099787 — EC50 = 130.0 nM 6.89
CHEMBL93006 — EC50 = 490.0 nM 6.31
CHEMBL329554 — EC50 = 590.0 nM 6.23
CHEMBL4073327 — EC50 = 1060.0 nM 5.97
CHEMBL482465 — EC50 = 11200.0 nM 4.95
CHEMBL4081770 — EC50 = 28010.0 nM 4.55
CHEMBL4080837 — EC50 = 41890.0 nM 4.38
CHEMBL4078094 — EC50 = 42370.0 nM 4.37
CHEMBL4097362 — EC50 = 47040.0 nM 4.33
CHEMBL329554 — EC90 = 42.74 uM -
CHEMBL93006 — EC90 = 82.49 uM -
CHEMBL5314362 ENTECAVIR EC90 > 1.0 uM -
CHEMBL4097362 — EC90 > 100.0 uM -
CHEMBL4070180 — EC90 = 1.97 uM -
CHEMBL4073327 — EC90 = 16.89 uM -
CHEMBL4080837 — EC90 > 100.0 uM -
CHEMBL4081770 — EC90 = 91.55 uM -
CHEMBL4099787 — EC90 = 2.86 uM -
CHEMBL4089642 — EC90 = 0.62 uM -
CHEMBL141 LAMIVUDINE EC90 > 2.0 uM -
CHEMBL5314362 ENTECAVIR EC50 < 10.0 nM -
CHEMBL2030736 — EC50 > 100000.0 nM -
CHEMBL4062343 — EC90 > 100.0 uM -
CHEMBL2030736 — EC90 > 100.0 uM -
CHEMBL4062343 — EC50 > 100000.0 nM -
CHEMBL4082499 — EC90 > 100.0 uM -
CHEMBL4082499 — EC50 > 100000.0 nM -
CHEMBL270618 — EC50 > 100000.0 nM -
CHEMBL482465 — EC90 > 100.0 uM -
CHEMBL270618 — EC90 > 100.0 uM -
CHEMBL4078094 — EC90 > 100.0 uM -
CHEMBL519667 — EC90 > 100.0 uM -
CHEMBL519667 — EC50 > 1650.0 nM -