Assay Detail
Binding
CHEMBL4040642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.40 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070016 | — | — | 1 | 5.71 |
| CHEMBL4086897 | — | — | 1 | 5.71 |
| CHEMBL4094610 | — | — | 1 | 5.64 |
| CHEMBL4067156 | — | — | 1 | 5.57 |
| CHEMBL4089508 | — | — | 1 | 5.42 |
| CHEMBL422904 | 22(R)-HYDROXYCHOLESTEROL | — | 1 | 5.32 |
| CHEMBL4078083 | — | — | 1 | 5.22 |
| CHEMBL4097209 | — | — | 1 | 5.14 |
| CHEMBL4061349 | — | — | 1 | 4.90 |
| CHEMBL4075566 | — | — | 1 | - |
| CHEMBL4103057 | — | — | 1 | - |
| CHEMBL4104778 | — | — | 1 | - |
| CHEMBL4085972 | — | — | 1 | - |
| CHEMBL4064438 | — | — | 1 | - |
| CHEMBL4085724 | — | — | 1 | - |
| CHEMBL4073435 | — | — | 1 | - |
| CHEMBL4059545 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070016 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4086897 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4094610 | — | EC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4067156 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4089508 | — | EC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL422904 | 22(R)-HYDROXYCHOLESTEROL | EC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL4078083 | — | EC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL4097209 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4061349 | — | EC50 | = | 12720.0 | nM | 4.90 |
| CHEMBL4075566 | — | EC50 | - | — | - | |
| CHEMBL4103057 | — | EC50 | - | — | - | |
| CHEMBL4104778 | — | EC50 | - | — | - | |
| CHEMBL4085972 | — | EC50 | - | — | - | |
| CHEMBL4064438 | — | EC50 | - | — | - | |
| CHEMBL4085724 | — | EC50 | - | — | - | |
| CHEMBL4073435 | — | EC50 | - | — | - | |
| CHEMBL4059545 | — | EC50 | - | — | - |