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Assay Detail

CHEMBL4040718

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Functional
Antioxidant activity assessed as ABTS radical scavenging activity measured each minute for 15 mins by spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models.
Teixeira J, Cagide F, Benfeito S, Soares P, Garrido J, Baldeiras I, Ribeiro JA, Pereira CM, Silva AF, Andrade PB, Oliveira PJ, Borges F.
J Med Chem (2017) 60 : 7084 -7098
PubMed 28745898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 4.75 5.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4095321 1 5.12
CHEMBL4066267 1 5.06
CHEMBL4087621 1 4.91
CHEMBL145 CAFFEIC ACID 3.0 1 4.75
CHEMBL4104012 1 4.63
CHEMBL4079747 1 4.55
CHEMBL4096250 1 4.52
CHEMBL4068979 1 4.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4095321 IC50 = 7500.0 nM 5.12
CHEMBL4066267 IC50 = 8700.0 nM 5.06
CHEMBL4087621 IC50 = 12200.0 nM 4.91
CHEMBL145 CAFFEIC ACID IC50 = 17900.0 nM 4.75
CHEMBL4104012 IC50 = 23500.0 nM 4.63
CHEMBL4079747 IC50 = 27900.0 nM 4.55
CHEMBL4096250 IC50 = 30500.0 nM 4.52
CHEMBL4068979 IC50 = 33300.0 nM 4.48