Assay Detail
Binding
CHEMBL4040840
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Inhibition of human recombinant microsomal MAOB expressed in baculovirus infected BTI-TN-5B1- 4 cells using p-tyramine as substrate assessed as decrease in H2O2 production after 15 mins by amplex red-based fluorescence assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.49 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4074532 | — | — | 1 | 8.40 |
| CHEMBL4060916 | — | — | 1 | 8.38 |
| CHEMBL494798 | — | — | 1 | 8.29 |
| CHEMBL4076698 | — | — | 1 | 8.22 |
| CHEMBL494808 | — | — | 1 | 8.12 |
| CHEMBL4080704 | — | — | 1 | 8.04 |
| CHEMBL4078090 | — | — | 1 | 7.99 |
| CHEMBL494800 | — | — | 1 | 7.96 |
| CHEMBL522532 | — | — | 1 | 7.86 |
| CHEMBL495466 | — | — | 1 | 7.82 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.78 |
| CHEMBL4094520 | — | — | 1 | 7.77 |
| CHEMBL4089520 | — | — | 1 | 7.72 |
| CHEMBL4099648 | — | — | 1 | 7.71 |
| CHEMBL4073128 | — | — | 1 | 7.67 |
| CHEMBL4072004 | — | — | 1 | 7.66 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 7.64 |
| CHEMBL4070614 | — | — | 1 | 7.38 |
| CHEMBL4081233 | — | — | 1 | 7.34 |
| CHEMBL4074339 | — | — | 1 | 7.34 |
| CHEMBL1598233 | — | — | 1 | 7.33 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.30 |
| CHEMBL4089098 | — | — | 1 | 7.11 |
| CHEMBL4085981 | — | — | 1 | 6.95 |
| CHEMBL4099251 | — | — | 1 | 6.82 |
| CHEMBL4075920 | — | — | 1 | 6.68 |
| CHEMBL4081648 | — | — | 1 | 6.64 |
| CHEMBL4091517 | — | — | 1 | 6.29 |
| CHEMBL4097014 | — | — | 1 | 6.21 |
| CHEMBL4102366 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4074532 | — | IC50 | = | 3.94 | nM | 8.40 |
| CHEMBL4060916 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL494798 | — | IC50 | = | 5.07 | nM | 8.29 |
| CHEMBL4076698 | — | IC50 | = | 5.95 | nM | 8.22 |
| CHEMBL494808 | — | IC50 | = | 7.52 | nM | 8.12 |
| CHEMBL4080704 | — | IC50 | = | 9.03 | nM | 8.04 |
| CHEMBL4078090 | — | IC50 | = | 10.31 | nM | 7.99 |
| CHEMBL494800 | — | IC50 | = | 11.08 | nM | 7.96 |
| CHEMBL522532 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL495466 | — | IC50 | = | 15.32 | nM | 7.82 |
| CHEMBL972 | SELEGILINE | IC50 | = | 16.73 | nM | 7.78 |
| CHEMBL4094520 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL4089520 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL4099648 | — | IC50 | = | 19.43 | nM | 7.71 |
| CHEMBL4073128 | — | IC50 | = | 21.35 | nM | 7.67 |
| CHEMBL4072004 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 23.07 | nM | 7.64 |
| CHEMBL4070614 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL4081233 | — | IC50 | = | 45.42 | nM | 7.34 |
| CHEMBL4074339 | — | IC50 | = | 45.4 | nM | 7.34 |
| CHEMBL1598233 | — | IC50 | = | 47.24 | nM | 7.33 |
| CHEMBL887 | RASAGILINE | IC50 | = | 49.66 | nM | 7.30 |
| CHEMBL4089098 | — | IC50 | = | 78.22 | nM | 7.11 |
| CHEMBL4085981 | — | IC50 | = | 113.5 | nM | 6.95 |
| CHEMBL4099251 | — | IC50 | = | 151.6 | nM | 6.82 |
| CHEMBL4075920 | — | IC50 | = | 210.8 | nM | 6.68 |
| CHEMBL4081648 | — | IC50 | = | 228.6 | nM | 6.64 |
| CHEMBL4091517 | — | IC50 | = | 512.6 | nM | 6.29 |
| CHEMBL4097014 | — | IC50 | = | 621.7 | nM | 6.21 |
| CHEMBL4102366 | — | IC50 | = | 674.2 | nM | 6.17 |