Assay Detail

CHEMBL4041202

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Functional

Antiproliferative activity against gefitinib resistant EGFR-mutated human HCC827 cells after 72 hrs by MTT assay

ChEMBL ↗

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Target

HCC827 (CHEMBL4296422) ↗

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Primary target HCC827

CHEMBL4296422

Anchored from Assay target.

Protein identity HCC827

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HCC827
Confidence	1 — Organism
Curated By	Autocuration

Target

HCC827 (CHEMBL4296422) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer.

Morgillo F, Amendola G, Della Corte CM, Giacomelli C, Botta L, Di Maro S, Messere A, Ciaramella V, Taliani S, Marinelli L, Trincavelli ML, Martini C, Novellino E, Ciardiello F, Cosconati S.
J Med Chem (2017) 60 : 7447 -7458
PubMed 28787156 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.70	7.10
Activity	2	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL254760	—	—	2	7.10
CHEMBL1230609	FORETINIB	2.0	2	6.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL254760	—	IC50	=	80.0	nM	7.10
CHEMBL1230609	FORETINIB	IC50	=	500.0	nM	6.30
CHEMBL1230609	FORETINIB	Activity		-	—	-
CHEMBL254760	—	Activity		-	—	-