Assay Detail
Binding
CHEMBL4041244
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PAM antagonist activity at CB1 receptor in CD-1 mouse cerebellar membranes assessed as increase in [3H]CP55,940 binding after 90 mins relative to control
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| EC50 | 1 | 6.10 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078901 | — | — | 2 | 6.10 |
| CHEMBL559612 | CP-55940 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078901 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4078901 | — | Activity | = | 214.7 | % | - |
| CHEMBL559612 | CP-55940 | Activity | - | — | - |