Assay Detail
Binding
CHEMBL4041379
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Inhibition of Plasmodium falciparum HGPRT using PRib-PP as the substrate by spectrophotometric method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.83 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086362 | — | — | 1 | 7.16 |
| CHEMBL2325754 | — | — | 1 | 6.30 |
| CHEMBL4064903 | — | — | 1 | 6.05 |
| CHEMBL4078513 | — | — | 1 | 5.70 |
| CHEMBL4102796 | — | — | 1 | 5.52 |
| CHEMBL4067618 | — | — | 1 | 5.40 |
| CHEMBL2325753 | — | — | 1 | 5.30 |
| CHEMBL4066772 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086362 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2325754 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4064903 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL4078513 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4102796 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4067618 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL2325753 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL4066772 | — | Ki | = | 6000.0 | nM | 5.22 |