Assay Detail
Functional
CHEMBL4041761
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H3122 cells after 72 hrs by SRB assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H3122 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.02 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4083722 | — | — | 1 | 8.70 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.85 |
| CHEMBL4076047 | — | — | 1 | 7.72 |
| CHEMBL4105335 | — | — | 1 | 7.55 |
| CHEMBL4101324 | — | — | 1 | 7.47 |
| CHEMBL4073419 | — | — | 1 | 7.47 |
| CHEMBL4096929 | — | — | 1 | 7.43 |
| CHEMBL4093385 | — | — | 1 | 7.41 |
| CHEMBL4092797 | — | — | 1 | 7.40 |
| CHEMBL4072042 | — | — | 1 | 7.38 |
| CHEMBL4074892 | — | — | 1 | 7.19 |
| CHEMBL4083380 | — | — | 1 | 7.11 |
| CHEMBL4093400 | — | — | 1 | 7.10 |
| CHEMBL4095108 | — | — | 1 | 7.09 |
| CHEMBL4062362 | — | — | 1 | 7.05 |
| CHEMBL4082518 | — | — | 1 | 7.05 |
| CHEMBL4090031 | — | — | 1 | 6.87 |
| CHEMBL4077202 | — | — | 1 | 6.86 |
| CHEMBL4077514 | — | — | 1 | 6.83 |
| CHEMBL4078145 | — | — | 1 | 6.83 |
| CHEMBL4068951 | — | — | 1 | 6.79 |
| CHEMBL4076195 | — | — | 1 | 6.64 |
| CHEMBL4098075 | — | — | 1 | 6.56 |
| CHEMBL4063033 | — | — | 1 | 6.20 |
| CHEMBL4070995 | — | — | 1 | 5.95 |
| CHEMBL4100533 | — | — | 1 | 5.81 |
| CHEMBL4071988 | — | — | 1 | 5.35 |
| CHEMBL4071863 | — | — | 1 | - |
| CHEMBL4077012 | — | — | 1 | - |
| CHEMBL4105667 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4083722 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4076047 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4105335 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4101324 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4073419 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4096929 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4093385 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4092797 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4072042 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4074892 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4083380 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4093400 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4095108 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4062362 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4082518 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4090031 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4077202 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4077514 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4078145 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4068951 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4076195 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL4098075 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL4063033 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL4070995 | — | IC50 | = | 1128.0 | nM | 5.95 |
| CHEMBL4100533 | — | IC50 | = | 1534.0 | nM | 5.81 |
| CHEMBL4071988 | — | IC50 | = | 4471.0 | nM | 5.35 |
| CHEMBL4071863 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL4077012 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4105667 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4078956 | — | IC50 | > | 10000.0 | nM | - |