Assay Detail
Binding
CHEMBL4041794
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Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by spectrophotometric method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.72 | 4.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097406 | — | — | 1 | 4.93 |
| CHEMBL4067517 | — | — | 1 | 4.84 |
| CHEMBL4105111 | — | — | 1 | 4.82 |
| CHEMBL4079905 | — | — | 1 | 4.80 |
| CHEMBL4080877 | — | — | 1 | 4.77 |
| CHEMBL4070225 | — | — | 1 | 4.77 |
| CHEMBL4060476 | — | — | 1 | 4.74 |
| CHEMBL4089685 | — | — | 1 | 4.72 |
| CHEMBL4071884 | — | — | 1 | 4.70 |
| CHEMBL4061562 | — | — | 1 | 4.68 |
| CHEMBL4097932 | — | — | 1 | 4.59 |
| CHEMBL4082380 | — | — | 1 | 4.56 |
| CHEMBL4098875 | — | — | 1 | 4.43 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097406 | — | IC50 | = | 11630.0 | nM | 4.93 |
| CHEMBL4067517 | — | IC50 | = | 14450.0 | nM | 4.84 |
| CHEMBL4105111 | — | IC50 | = | 15240.0 | nM | 4.82 |
| CHEMBL4079905 | — | IC50 | = | 15970.0 | nM | 4.80 |
| CHEMBL4080877 | — | IC50 | = | 17020.0 | nM | 4.77 |
| CHEMBL4070225 | — | IC50 | = | 16940.0 | nM | 4.77 |
| CHEMBL4060476 | — | IC50 | = | 18220.0 | nM | 4.74 |
| CHEMBL4089685 | — | IC50 | = | 19130.0 | nM | 4.72 |
| CHEMBL4071884 | — | IC50 | = | 20170.0 | nM | 4.70 |
| CHEMBL4061562 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4097932 | — | IC50 | = | 25690.0 | nM | 4.59 |
| CHEMBL4082380 | — | IC50 | = | 27710.0 | nM | 4.56 |
| CHEMBL4098875 | — | IC50 | = | 37440.0 | nM | 4.43 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 817380.0 | nM | - |