Assay Detail
Functional
CHEMBL4041799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity in human MCF7 cells assessed as cell viability after 48 hrs by alamarBlue assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.32 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL465843 | PIPLARTINE | — | 1 | 5.92 |
| CHEMBL4088441 | — | — | 1 | 5.47 |
| CHEMBL3187610 | — | — | 1 | 5.46 |
| CHEMBL4066386 | — | — | 1 | 5.43 |
| CHEMBL4064780 | — | — | 1 | 5.12 |
| CHEMBL4075289 | — | — | 1 | 5.09 |
| CHEMBL4077303 | — | — | 1 | 5.07 |
| CHEMBL4075816 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL465843 | PIPLARTINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4088441 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3187610 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4066386 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4064780 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4075289 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4077303 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4075816 | — | IC50 | = | 9600.0 | nM | 5.02 |