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Assay Detail

CHEMBL4041847

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human GSK3beta using YRRAAVPPSPSLSRHSSPHQS(PO4)EDEEENH as substrate after 60 mins in presence of [gamma32P]ATP by TopCount method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen synthase kinase-3 beta (CHEMBL262)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Natural and synthetic bioactive inhibitors of glycogen synthase kinase.
Khan I, Tantray MA, Alam MS, Hamid H.
Eur J Med Chem (2017) 125 : 464 -477
PubMed 27689729 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.55 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL326705 1 6.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL326705 IC50 = 280.0 nM 6.55