Assay Detail
Binding
CHEMBL4041924
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method
22
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.78 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20338 | — | — | 2 | 6.93 |
| CHEMBL1223683 | — | — | 2 | 6.90 |
| CHEMBL4102243 | — | — | 2 | 6.67 |
| CHEMBL91576 | — | — | 2 | 6.62 |
| CHEMBL4092578 | — | — | 2 | 5.96 |
| CHEMBL4061504 | — | — | 2 | 5.52 |
| CHEMBL4099779 | — | — | 2 | 5.42 |
| CHEMBL4085023 | — | — | 2 | 5.38 |
| CHEMBL4096444 | — | — | 2 | 4.89 |
| CHEMBL4062122 | — | — | 2 | 4.79 |
| CHEMBL4084820 | — | — | 2 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20338 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL20338 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL1223683 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL1223683 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL4102243 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL4102243 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL91576 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL91576 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4092578 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL4092578 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL4061504 | — | Ki | = | 3018.0 | nM | 5.52 |
| CHEMBL4061504 | — | Ki | = | 3018.0 | nM | 5.52 |
| CHEMBL4099779 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL4099779 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL4085023 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL4085023 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL4096444 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL4096444 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL4062122 | — | Ki | = | 16400.0 | nM | 4.79 |
| CHEMBL4062122 | — | Ki | = | 16400.0 | nM | 4.79 |
| CHEMBL4084820 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL4084820 | — | Ki | = | 30000.0 | nM | 4.52 |