Assay Detail
Binding
CHEMBL4041925
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Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.14 | 5.17 |
| Ki | 2 | 5.14 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4077914 | — | — | 2 | 5.17 |
| CHEMBL25725 | — | — | 2 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4077914 | — | EC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL4077914 | — | Ki | = | 6750.0 | nM | 5.17 |
| CHEMBL25725 | — | EC50 | = | 7780.0 | nM | 5.11 |
| CHEMBL25725 | — | Ki | = | 7780.0 | nM | 5.11 |