Assay Detail
Binding
CHEMBL4041926
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Antagonist activity at D3 receptor (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.93 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099779 | — | — | 1 | 9.30 |
| CHEMBL1223683 | — | — | 1 | 9.22 |
| CHEMBL1223748 | — | — | 1 | 9.00 |
| CHEMBL1223750 | — | — | 1 | 9.00 |
| CHEMBL4078910 | — | — | 1 | 8.55 |
| CHEMBL1223749 | — | — | 1 | 8.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099779 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1223683 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1223748 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1223750 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4078910 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL1223749 | — | Ki | = | 3.1 | nM | 8.51 |