Assay Detail
Binding
CHEMBL4041928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.27 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1223683 | — | — | 1 | 8.00 |
| CHEMBL1223749 | — | — | 1 | 7.52 |
| CHEMBL1179089 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1223683 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1223749 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1179089 | — | Ki | = | 500.0 | nM | 6.30 |