Assay Detail
Functional
CHEMBL4042007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KCL22 cells harboring ABL1 T315I mutant assessed as reduction in cell viability after 48 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KCL-22 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.33 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493883 | — | — | 1 | 6.64 |
| CHEMBL494685 | — | — | 1 | 6.51 |
| CHEMBL3216659 | — | — | 1 | 6.37 |
| CHEMBL495306 | — | — | 1 | 6.33 |
| CHEMBL493656 | — | — | 1 | 6.30 |
| CHEMBL3215571 | — | — | 1 | 6.19 |
| CHEMBL494867 | — | — | 1 | 6.18 |
| CHEMBL3216893 | — | — | 1 | 6.11 |
| CHEMBL495093 | — | — | 1 | - |
| CHEMBL523714 | — | — | 1 | - |
| CHEMBL522537 | — | — | 1 | - |
| CHEMBL3216218 | — | — | 1 | - |
| CHEMBL522503 | — | — | 1 | - |
| CHEMBL3216892 | — | — | 1 | - |
| CHEMBL493657 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493883 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL494685 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3216659 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL495306 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL493656 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3215571 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL494867 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3216893 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL495093 | — | IC50 | - | — | - | |
| CHEMBL523714 | — | IC50 | - | — | - | |
| CHEMBL522537 | — | IC50 | - | — | - | |
| CHEMBL3216218 | — | IC50 | - | — | - | |
| CHEMBL522503 | — | IC50 | - | — | - | |
| CHEMBL3216892 | — | IC50 | - | — | - | |
| CHEMBL493657 | — | IC50 | - | — | - |